THE NUTBRAIN STUDY PROJECT
Exploring the complex relationship between Nutrition, gUT microbiota and BRain AgING.
The NutBrain Study aims at investigating the association of dietary habits with brain ageing, and their role in modulating the gut microbiota composition, and brain measures as well.
This is a population-based cohort study of community-dwelling adults aged 65 years or more living in Northern Milan, Italy. At the point of presentation, people are screened for cognitive functions. Socio-demographic characteristics along with lifestyles and dietary habits, medical history, drugs, functional status, and anthropometric measurements are also recorded. Based on the cognitive screening score, a sub-sample undergo a clinical evaluation including a neurological examination and a Magnetic Resonance Imaging (MRI) scanning (both structural and functional). Stool and blood samples for the gut microbiota analysis and for the evaluation of biological markers are also collected.
Eligible participants
The NutBrain study targets all over-65 years old residing in Milan and its province. Participation is free and voluntary and does not require any cost. The eligible population is contacted by means of a letter of invitation, in which people are invited to contact the ITB-CNR by phone to schedule the first visit during which he/she is asked to bring the last instrumental and clinical exams prescribed by their general practitioner. Participants are visited at the research facility in their residence town by a trained team. The informed consent form is completed at the research facility prior to data collection.
In total 540 participants were screened (mean age 74 years ± 6.5 SD, 59.9% females) and 180 were recruited for the clinical examination.
Relevance and expected impacts
The NutBrain is an innovative study that incorporates modern and advanced technologies (i.e. microbiome and neuroimaging) into the traditional epidemiologic design. The study represents a unique opportunity to address key questions about the role of modifiable risk factors on cognitive impairment, with a particular focus on dietary habits and their association with gut microbiota and markers of the brain-ageing process. These findings will help to encourage and plan lifestyle interventions, for both prevention and treatment, aiming at promoting healthy cognitive ageing.
— STUDY COORDINATION —
The study is coordinated by the Institute of Biomedical Technologies – National Research Council (ITB-CNR) of Segrate (MI, Italy) and by the IRCCS Fondazione Istituto Neurologico C. Mondino of Pavia (Italy). The project was approved by the Ethics Committee of Pavia.
The study is funded by the Italian Ministry of Health (GR-2016-02361730730).
The protocol is registered at ClinicalTrials.Gov (NCT04461951).
— RESEARCH STAFF —
Federica Prinelli (PI) — Sara Bernini (CO-PI) — Marco Severgnini (UO Leader)
Team Members: Fulvio Adorni, Silvia Conti, Maria Lea Correa Leite, Alfredo Costa, Matteo Cotta Ramusino, Nithiya Jesuthasan, Massimo Musicco, Orietta Pansarasa, Elena Perdixi, Anna Pichiecchio, and Elena Sinforiani
IT Staff to support research activities: Aleksandra Soijc and Nicola Losito
Scientific Administrative Staff: Emanuela Gerosa and Gianfranca Lovicu
Illustrations: Stefano Fabbri
PUBLICATIONS
Exploring the relationship between Nutrition, gUT microbiota, and BRain AgINg in community-dwelling seniors: the Italian NutBrain population-based cohort study protocol.
Prinelli F, Jesuthasan N, Severgnini M, Musicco M, Adorni F, Correa Leite ML, Crespi C, and Bernini S.
BMC Geriatrics (2020) 23;20(1):253.
https://doi.org/10.1186/s12877-020-01652-2